Carbon and nitrogen are the two most abundant nutrients for all living organisms. Carbon and nitrogen metabolism are tightly coupled and coordinated by various metabolites and signaling pathways. What are the molecular mechanisms that sense and control carbon and nitrogen metabolism following environmental nutrient changes in plants?
To understand the mechanisms that regulate carbon/nitrogen metabolism, researchers led by Prof. Zuo Jianru and Prof. Li Jiayang from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) identified that the key factors OsHXK7 and ARE4 link glucose signaling to nitrogen utilization in rice. The results were published in Developmental Cell on July 5.
In this study, the researchers found that the MYB-related transcription factor ARE4 is retained in the cytosol in a complex with the glucose sensor OsHXK7. When a glucose signal is detected, ARE4 is released, translocated to the nucleus, and activates the expression of a subset of high-affinity nitrate transporter genes, thereby increasing nitrate uptake and accumulation.
Further studies revealed that the ARE4 regulatory scheme exhibits a diurnal pattern in response to circadian changes in soluble sugars, and the overexpression of ARE4 increases rice grain size.
These results reveal a previously unknown mechanism by which the OsHXK7-ARE4 complex detects a sugar signal and then promotes nitrogen utilization, directly linking carbon and nitrogen metabolism. This study may identify good targets for breeding high-yielding cultivars.
Xiaohui Ma et al, Link glucose signaling to nitrogen utilization by the OsHXK7-ARE4 complex in rice, Developmental Cell (2023). DOI: 10.1016/j.devcel.2023.06.003
Awarded by the Chinese Academy of Sciences
Citation: Scientists reveal molecular interaction in carbon/nitrogen metabolism in rice (2023, July 10) retrieved 11 July 2023 from https://phys.org/news/2023-07-scientists-reveal-molecular-interaction- carbonnitrogen.html
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