A new treatment paves the way for reducing antimicrobial resistance in the treatment of a deadly infection in chickens, according to an international team of researchers led by the University of Surrey. The groundbreaking study investigated the efficacy of a novel metal-derived complex in the treatment of Avian Pathogenic Escherichia coli (APEC), a serious respiratory infection in chickens that has become increasingly resistant to antibiotics. A growing body of evidence shows that APEC can potentially spread to humans.
The international research group also includes the University of Surrey, Animal and Plant Health Agency, University of Connecticut, University of Sheffield and Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg. The study was published in the journal Veterinary Microbiology.
Professor Roberto La Ragione, Professor of Veterinary Microbiology and Pathology at the University of Surrey, said, “Antimicrobial resistance is one of the greatest threats to human and animal health. related welfare issues, but also increases the possibility that it will spread.
“Coronavirus shows how quickly a pandemic can happen, and the threat of another is more likely that antibiotics to treat simple bacterial infections no longer work.”
To test the effectiveness of the metal complex, manganese carbonyl, the researchers worked with Greater Wax Moth larvae and APEC. Divided into two groups, the first received manganese carbonyl, while the second, the controls, received phosphate-buffered saline (PBS) or dimethyl sulfoxide (DMSO). After four days, the survival rate for the worms that received manganese carbonyl was between 56% and 75%, while in the control group, the survival rate was between 25% and 45% (PBS) and 19% and 45% (DMSO) , which shows the protective effect of the complex.
The test was repeated with APEC-infected chickens, which again received manganese carbonyl or PBS. The shedding of bacteria identified in the feces of chickens was lower 24 hours after the treatment of those who received manganese carbonyl compared to the PBS control group, indicating the killing of bacteria caused by the compound. This was supported by caecal samples taken three days after treatment which also found significantly less bacteria in the manganese carbonyl recipients. Examination of tissue samples from the birds’ livers showed no toxic effects from the metal compound, which was seen in the worms.
Dr. Jonathan Betts, a research fellow at the University of Surrey School of Veterinary Medicine, said, “The development of alternatives to antibiotics is essential to protect our future health. Metal complexes such as manganese carbonyl can do this, as we have shown which is not. it is just as effective, but cheaper to manufacture than traditional antibiotics.
“Discovering the efficacy of manganese carbonyl in the treatment of APEC is a big step forward in dealing with antimicrobial resistance because it shows that there is no need for additional antibiotics; we just need to think more innovatively.” or to improve treatments.”
Jonathan W. Betts et al, The manganese carbonyl complex [Mn(CO)3(tqa-κ3N)]Br: A new antimicrobial agent with potential to treat avian pathogenic Escherichia coli (APEC) infections, Veterinary Microbiology (2023). DOI: 10.1016/j.vetmic.2023.109819
Provided by the University of Surrey
Citation: New treatment to tackle antibiotic-resistant infections in chickens (2023, July 19) retrieved on July 19, 2023 from https://phys.org/news/2023-07-treatment-tackle- infections-resistant-antibiotics.html
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